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Gary Scheiner says

The scientific answer:  Slight difference in the amino acid sequence.  In Humalog, lysine and proline are switched.  In Novolog, proline is switched for aspartic acid.  The changes cause the molecules to repel eachother (avoiding aggregation) and accelerating absorption & action.
 
The practical answer:  The insulin action profiles and potency are virtually identical.  But there are some differences in the solutions in which the insulins are dissolved.  Novolog (aspart) has some extra buffering agents that seem to make it more resistant to deterioration and (at least in my experience) less likely to cause site irritation.

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